Muti modeled as a teenager and made her film debut in 1970 in La Moglie pił bella (aka The Most Beautiful Wife). She has primarily worked in Italian films but she made her American film debut in 1980 in Flash Gordon. Other American movies she appeared in include Oscar (1991) and Once Upon a Crime... (1992).
Muti has been married twice; to Alessio Orano (1975-1981) and Federico Facchinetti (1988-?). She is separated from Facchinetti and has been living with Stefano Piccolo since 1998. Muti has three children: an oldest daughter, Naike Rivelli, who is also an actress; and a son, Andrea, and daughter, Carolina, from her marriage to Facchinetti.
Muti was voted "The Most Beautiful Woman in the World" in 1994 by a world wide poll of readers of the magazine Class.