He was M.P. for Cambridgeshire, following the Whig traditions of his family; but after his succession to the earldom in 1790 he supported Pitt, and took office in 1801 as Lord Lieutenant of Ireland (1801-1806), where he supported Catholic emancipation. He was created K.G in 1803, and was a fellow of the Royal Society. He married Elizabeth, daughter of James Lindsay, 5th earl of Balcarres, in 1782, but left no son.
He was succeeded in the peerage by his nephew, Charles Philip Yorke.
See the duke of Buckingham, Memioirs of the Court and Cabinets of George III (4 vols., London, 1853-1855).
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