Piero was born in Cosio d' Arroscia, Liguria, Italy.
In Alba, Piedmont, Italy, with Asger Jorn and Giuseppe Pinot Gallizio he founded the Laboratory of immaginiste experiences as part of the International movement for an imaginist Bauhaus (IMIB).
He edited Eristica the magazine published by IMIB and September of 1956 he organised the First World-wide Conference of the Free Artists, with Jorn, Gallizio and Elena Verrone. He became Verrone's husband two years later. At the Cultural Union of Turin he helped put on a demonstartion unitary urbanism in December 1956.
In the summer of 1957 he took a holiday in his house in Cosio d' Arroscia. Here, with Michèle Bernstein, Guy Debord, Pinot Gallizio, Asger Jorn, Walter Olmo, Ralph Rumney and Elena Verrone the Situationist International was founded on July 28. Following a row with Debord, he left the organisation with Olmo and Verrone.
In 1962 he founded in Turin the CIRA (International Center for an Institute of Artistic Research) with the purpose to expand the proposals of the Alba Laboratory.
From 1968 he continued with his own artistic activity
From 1972 to 1996 Simondo worked at the University of Turin where he organised experimental activities at the Institute of Pedagogy. He held the chair of Methodology and Didactics of the Audovisual Medium .
Publications by Simondo include: