Co-ordinates of S. Latitude 47° 9′, W. Longitude 126° 43′ have been stated by Lovecraft but never investigated. August Derleth used the co-ordinates of S. Latitude 49° 51′, W. Longitude 128° 34′ in his own writings. The latter also places it about a day's journey from Pohnpei, an actual island of the area, which consequently plays a central part in the Cthulhu Mythos.
In Lovecraft's fictional Cthulhu Mythos, the most ubiquitous liturgical phrase is "Ph'nglui mglw'nafh Cthulhu R'lyeh wgah'nagl fhtagn!" -- "In his house at R'lyeh, dead Cthulhu waits/lies dreaming."