Young Richard's uncle, Richard III of England, took him to the Tower of London in mid-1483, and what happened to him and his brother -- the Princes in the Tower -- after that has been the subject of much speculation and debate ever since. In the 1490s, Perkin Warbeck claimed to be Richard, Duke of York, but he was an imposter. Richard's might have been the smaller of the two skeletons discovered in a chest in the Tower in 1674, but there is as yet no evidence one way or the other.
The comedy series The Black Adder features an alternative history where Richard succeeded his uncle to the throne as Richard IV of England (reigned 1485 - 1498) before being poisoned and succeeded by Henry VII.