In France, the grape is traditionally used in blends with another white wine grape, Marsanne. It is the only other white variety, besides Marsanne, allowed in France's northern Rhône appellationss of Crozes-Hermitage, Hermitage and St. Joseph, and in Châteauneuf-du-Pape. The Châteauneuf-du-Pape appellation also allows it to be blended into red wines.
The aroma of Roussanne is often reminiscent of a flowery herbal tea. Unlike some better known white wine grapes, wines based on Roussanne can mature gracefully, holding up well a decade or more after bottling.
It is a difficult variety to grow, with vulnerability to mildew, poor resistance to drought and wind, late and/or uneven ripening, and irregular yields.