Andrews was primarily a naturalist and an organizer of expeditions. His life was a long series of travels and explorations of desert islands, raging seas, remote mountains and deserts. Numerous encounters are reported with everything from angry whales and hungry sharks, to pythons and several brushes with armed Chinese bandits. He was erroneously reported dead at least once.
Andrews was married in 1914 and divorced in 1930. He had two sons.
Andrews is said to have been one of the models for movie legend Indiana Jones, and was a graduate of Beloit College, in the town of Beloit, Wisconsin where he was born.