Born in Shropshire, Henderson served in WWI, afterwards entering the Royal Academy of Music. He received his big break in 1925, when he preformed in Delius's A Mass of Life. But, he will be for ever immortalized for his rendition of Zarathustra, and the song was virtually his own for nearly 20 years.
Henderson's operatic preformances were many. He starred in such notewothy operas as: Idyll (1933) and Four Tudor Portraits (1936), by Vaughan Williams, Figaro and Don Giovanni, the last two being filmed by EMI.
Henderson retired from the stage in 1952 and devoted nearly all of his time to teaching and writing music.
Renewed interest in him was revived in 1999, when he celebrated his 100th birthday. There was even an album released for the occasion, entitled Roy Henderson: A Centenary Recital.