Shuggie Otis began performing professionally at the age of 12, often disguising himself with dark glasses and a false moustache so that he could play in nightclubs. He released his first solo album in 1970. The Brothers Johnson's version of his composition "Strawberry Letter 23" reached #1 in the Billboard rhythm and blues chart and #5 in the Billboard pop chart in 1977.
He also plays piano, organ, and bass. He has recorded with Frank Zappa, Al Kooper, Etta James, and Eddie Vinson.