Pérez became famous in the 1970s with the singing group Haciendo Punto en Otro Son, a group that scored many hits on Puerto Rican radio. With Haciendo Punto en Otro Son, he toured all of Puerto Rico and some other countries, recording various albums and 8-tracks.
After the group broke up, Pérez went into Puerto Rican television with the Los Rayos Gamma show. In Los Rayos Gamma, he teamed up with Sunshine Logrono, Jacobo Morales and Horacio Olivo to satirize Puerto Rican politics. Later on, he became the show host of the successful program, En Serio Con Silverio.
In 2000, he debuted in the show Anda Pal Cara. He also wrote, in 1996, a book named Humortivacion, which promotes motivation through humor. Currently, Pérez also hosts a radio show, Arranca en Fa!. Humortivacion had a sequel, Mas Humortivacion.
Pérez also writes a column in El Nuevo Dia newspaper.