A native of Baltimore, Maryland, Keibler is a former cheerleader for the Baltimore Ravens American Football team. In 1999 she entered a tryout from World Championship Wrestling to become one of their Nitro Girls, which she won.
While initially a Nitro Girl, she soon became a valet using the name Miss Hancock. After a feud with the Misfits in Action stable which she was used in a storyline, widely considered tasteless, involving a miscarriage, she began to use her real name.
When WCW was purchases by the WWF in 2001, her contract was one of twenty-four that were retained by the WWF, making her a WWF/WWE employee ever since.
Keibler is noted for her figure: her legs are 41 1/2 inches long. She has been linked romantically to her current boyfriend Luke Mancuso in her short professional wrestling career. Luke and Stacy are rumoured to get married February 14, 2004.