The work is in one continuous stretch with no breaks, but is divided in the score into four parts:
The mood of the first part is quite bleak, contrasting with the second part which is livlier and provides evidence of the inspiration Bartók's drew from Hungarian folk music, with dance-like melodies to the fore.
The work is even more harmonically adventurous and contrapuntally complex than Bartók's previous two string quartets and explores a number of extended instrumental techniques, including sul ponticello (playing with the bow over the fingerboard), col legno (playing with the wood rather than the hair of the bow), glissandi (sliding from one note to another) and the so-called Bartók pizzicato (plucking the string so that it rebounds against the instrument's fingerboard).
It has often been suggested that Bartók was inspired to write the piece after hearing a performance of Alban Berg's Lyric Suite (1926) in 1927. The piece is widely considered to be the most tightly constructed of Bartók's six string quartets, the whole deriving from a relatively small amount of thematic material integrated into a single continuous structure. It is also Bartók's shortest quartet, with a typical performance lasting around fifteen minutes.
The work is dedicated to the Musical Society Fund of Philadelphia and was entered into an international competition for chamber music run by the organisation. It won the $6,000 first prize jointly with a work by Alfredo Casella. The piece was premiered on February 19, 1929 by the Waldbauer-Kerpely Quartet.
The piece was first published in 1929 by Universal Edition.