Sullivan's Travels has been deemed "culturally significant" by the United States Library of Congress and selected for preservation in the National Film Registry.
Joel and Ethan Coen directed a film called O Brother, Where Art Thou; the film is loosely based on Homer's Odyssey and inverts the plot of Sullivan's Travels (in keeping with The Odyssey): a man breaks out of prison and tries to return home; there are many obstacles in his way.