By common sense, you might think that T-symmetry is obviously violated: we cannot remember the future, eggs are much easier to break than to reconstruct; in general, entropy increases. This is called the second law of thermodynamics, but in fact is not related in any obvious way to T-symmetry. The second law can be entirely attributed to the "initial conditions" of the universe, rather than the laws governing evolution. Decoherence in quantum mechanics is a similar phenomenon.
Many physicists believe T-symmetry is violated. This is because experiments have shown that CPT-symmetry holds, but that CP-symmetry is broken. It can be shown that if CP-symmetry is broken, there must be a balancing T-symmetry violation in order to preserve CPT-symmetry.
However, there is no consensus as to the exact nature of the T-symmetry violation. Gravity is a prime contender: the fact that gravity is only attractive, not repulsive, may point to a violation of T-symmetry. Black holes appear to violate T-symmetry: there are significant differences between black hole formation and evaporation (via Hawking radiation). Particle physicists are conducting experiments looking for T-symmetry violation in high-energy nuclear reactions.
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