The treaty came into force on 22 April 1968, and has now been signed and ratified by all 33 nations of Latin America and the Caribbean. (Cuba was the last country to ratify, on 23 October 2002.) Under the treaty, the states parties agree to prohibit and prevent the "testing, use, manufacture, production or acquisition by any means whatsoever of any nuclear weapons" and the "receipt, storage, installation, deployment and any form of possession of any nuclear weapons."
There are two additional protocols to the treaty: Protocol I binds those overseas countries with territories in the region (the United States, the United Kingdom, France, and the Netherlands) to the terms of the treaty. Protocol II requires the world's declared nuclear weapons states to refrain from undermining in any way the nuclear-free status of the region; it has been signed and ratified by the USA, the UK, France, China, and Russia.
The treaty also provides for a comprehensive control and verification mechanism, overseen by the Agency for the Prohibition of Nuclear Weapons in Latin America and the Caribbean (OPANAL), based in Mexico City.
Alfonso García Robles and Alva Myrdal received the Nobel Peace Prize in 1982 for their efforts in promoting the treaty.