The first Charleston was a galley mounting one 24-pounder gun, identical to Mars (length 52 ft, breadth 15 ft, depth 5.1 ft, complement 28). She was built at Charleston in 1798, commanded by "Captain-of-a-Galley" James Payne, and used to defend the coast of South Carolina during the Quasi-War with France. The ship was sold in Charleston around 1 February1802.
The fourth Charleston (PG-51) was a patrol boat used in World War II.
The fifth(?) Charleston (LKA-113) (originally AKA-113) was an amphibious cargo ship commissioned 1968 and decommissioned 1992, and mothballed at Portsmouth, Virginia.