Starting in 1914, the couple operated several dance clubs in the New York City area, and toured with their dance routines. They made several silent films together, beginning with Patria in 1917, but Vernon served as a pilot during World War I, and died in an airplane crash near Fort Worth, Texas.
Irene married three more times, to Robert Treman, Frederic McLaughlin and George Enzinger. She acted in a few mostly forgettable films, and saw her stories about her life with Vernon made into a movie, The Story of Vernon and Irene Castle, in 1939. She served as a technical advisor on the film.