Wuyashu was born to Shizu (Wanyan Helibo) in 1061 and inherited from his uncle Muzong (Wanyan Yingge) in 1104. Muzong died in the middle of the conquest of Helandian (曷懶甸, Hamgyŏngdo, North Korea) after pacifying the Tumen River basin. Wuyashu resumed the project in the next year. Under his order, Shi Shihuan (石適歡) led Jurchen army of the Tumen River basin, subdued Jurchen in Helandian and advanced southward to chase about 1,800 remnants who defected to Goryeo. Goryeo did not hand them over but sent Im Gan (林幹) to intercept the Wanyan army. However, Shi Shihuan defeated Im Gan north of the Chŏngp'ŏyng wall and invaded northeastern frontier of Goryeo. Goryeo dispatched Yun Gwan (尹瓘) but lost a battle again. As a result, Wuyashu subjugated the Jurchen in Helandian.
In 1107 Goryeo dispatched five large armies led by Yun Gwan to Helandian. They destroyed a hundred Jurchen villages and built nine fortresses there. After one-year battle, the Wanyan army won two fortresses and eliminated Goryeo reinforcements. Goryeo and the Jurchen achieved settlement and, as a result, Goryeo withdrew from the occupied areas.
He also pacified the Suifen River basin. When he died in 1113, his younger brother Aguda succeeded.