Mouzon moved to Philadelphia, long considered one of the best boxing school cities in the United States by experts, when he was little. In Philadelphia, he learned how to box.
Mouzon is better known in the boxing world for the results he obtained against two former world champions: Ike Williams and Bob Montgomery. He drew (tied) with Williams, and beat Montgomery by knockout. His career had a sudden finish, however, when rematched with Montgomery: He lost by knockout in their second bout, and suffered a detached retina. Because at that era medical technology lagged in the area of ofthalmology, detached retinas meant automatic retirement for fighters, and Mouzon had to retire at the young age of 19. He had a record of 23 wins, 3 losses and 1 draw, with 9 wins by knockout.
Mouzon went on to train some recognizable boxing figures, such as the former two time world champion Dwight Muhammad Qawi and Roy Jones Jr title challenger Tony Thornton.
On July 1, 2003, he passed away after suffering from kidney cancer.