The village name 'Weston' is Anglo Saxon in origin, and means 'western estate'. In the Domesday Book of 1086 the village is recorded as Westone. The affix 'Turville' was added later, referring to manorial family of the village in the Thirteenth century, and to differentiate the village from other places called Weston.
A notable resident of the village in the Sixteenth century was Dr John Colet. It is after him that the John Colet School in nearby Wendover is named. Weston Turville was also at one time, one of the main places where Aylesbury ducks were bred.