The school is formerly known as Wheeling College, and Wheeling Jesuit College.
The campus houses two prominent NASA buildings: the Robert C. Byrd National Technology Transfer Center (NTTC) and the Erma Ora Byrd Center for Educational Technologies (CET). The CET building is the official home of NASA's Classroom of the Future.
Wheeling Jesuit University is a member of the NCAA Division II, and the West Virginia Intercollegiate Athletic Conference (WVIAC).