April 21 - Battle of Cerignola. Spanish forces under Hernandez Gonzalo de Cordoba defeat the French under the Duc de Nemours, who is killed. Considered to be the first battle in history won by gunpowder small arms.
December 29 - Battle of the Garigliano - Spanish forces under Cordoba defeat a French-Italian mercenary army under the Marquis of Saluzzo. The French forces withdraw to Gaeta