After initial tours in Hong Kong and Bangkok, Bodine spent her career working primarily on Southwest Asia and the Arabian Peninsula. She has twice served in the Bureau of Near East Affairs' Office of Arabian Peninsula Affairs, first as Country Officer for the Yemenis, then as Political-Military officer for the peninsula. She later served as Deputy Office Director. Ambassador Bodine has also had assignments as Deputy Principal Officer in Baghdad, and as Deputy Chief of Mission in Kuwait during the Iraqi invasion and occupation in 1990. She was awarded the Secretary of State's Award for Valor for her work in occupied Kuwait. See the Gulf War.
Following Kuwait, Bodine was the Associate Coordinator for Operations and later served as the Acting Coordinator for Counterterrorism. She went on to serve as the Dean of Professional Studies at the Department's Foreign Service Institute. She has worked on the secretariat staff of Secretaries Kissinger and Vance, and as a Congressional Fellow in the office of Senator Robert Dole. Most recently, Ms. Bodine spent a year as the Director of East African Affairs.
On 7 November 1997, Bodine was appointed to be Ambassador to the Republic of Yemen. During her posting in Sanaa, the destroyer Cole was bombed in a terrorist attack. In 1999, she negotiated for hours to release three Americans kidnapped in Yemen. In 2001, a flight carrying Ambassador Bodine and 90 other passengers from Yemen was hijacked mid-flight. The plane was diverted to Africa, where it landed without further incident.
Ms. Bodine's career was marked by controversy when details of her conflict with the FBI investigation of the Cole bombing came to light. According to a PBS documentary, Ms. Bodine's actions may have contributed to the intelligence failure that resulted in the 9/11 bombing of the World Trade Center.
She then became Diplomat in Residence at the University of Southern California, Santa Barbara, until the March 2003 Invasion of Iraq, when she was appointed coordinator for central Iraq in charge of Baghdad.