Major tributaries include Cabramatta Creek, Prospect Creek, Salt Pan Creek and the Woronora River. The Georges River is popular for recreational activities such as water skiing and swimming. The banks of the river along the lower reaches are marked by large inlets and indentations overlooked by steep sandstone ridges and scarps, many being home to expensive residential properties.
The Georges River features some artificial lakes in the suburb of Chipping Norton, near Liverpool. These lakes, known as the Chipping Norton Lakes, are the result of sand mining and quarrying operations in the twentieth century. The Lakes are now a popular watersports and recreational facility for the residents of the south-western suburbs of Sydney.
A weir was constructed across the river adjacent to Liverpool railway station in the nineteenth century - Liverpool Weir now forms the uppermost tidal limit and presence of salt water on the Georges River.