Kenner was born in Peterborough, Ontario; his father was a classics professor. He attributed his interest in literature to his poor hearing, caused by a bout of influenza during his childhood.
His first teaching post was at Santa Barbara College; he then taught at Johns Hopkins University (from 1973 to 1990) and the University of Georgia (from 1990 to 1999).
One of his strongest influences was Marshall McLuhan, who wrote the introduction to Kenner's first book Paradox in Chesterton. Kenner's PhD dissertation at Yale, The Poetry of Ezra Pound (1951) was dedicated to McLuhan. (Pound, who became a friend of Kenner's, had suggested the thesis be titled The Rose in the Steel Dust.) Kenner recently said of McLuhan "I had the advantage of being exposed to Marshall when he was at his most creative, and then of getting to the far end of the continent shortly afterward, when he couldn't get me on the phone all the time. He could be awfully controlling."
Kenner's books included: