She made her debut in Interview with the Vampire, the film based on the Anne Rice novel of the same name. Her most famous performance to date was in Spider-Man
She has starred in other movies, like The Virgin Suicides, All I Wanna Do, Drop Dead Gorgeous, Dick, Bring it On, Get Over It, Crazy/Beautiful, and Mona Lisa Smile.
She won the 2002 Best Actress Silver Ombú at the Mar de Plata Film Festival for her performance as Marion Davies in Peter Bogdanovich's The Cat's Meow.