While ontological relativity does not invalidate the principle of falsifiability first presented by Karl Popper, Popper himself acknowledged that continual ad hoc modification of a theory provides a means for a theory to avoid being falsified. In this respect, the principle of parsimony, or Occam's Razor, plays a role. This principle presupposes that between multiple theories explaining the same phenomenon, the simplest theory--in this case, the one that is least susceptible to continual ad hoc modification--is to be preferred.
External reference
W. V. Quine 1968 Ontological Relativity Available at http://www.unlv.edu/Colleges/Liberal_Arts/Philosophy/Ontological%20Relativity.htm