In 1836, four Presbyterian ministers missionaries came to the Oregon Country to start another mission. This group was made up of Narcissa Prentiss Whitman and her husband Marcus Whitman, a doctor, who were both from New York. Another couple, Henry Harmon Spalding (who had been jilted by Narcissa) and his wife Eliza were also part of the group. Narcissa and Eliza were the first white women to cross the Rocky mountains.
The Whitmans reached the Walla Walla river on September 1, 1836 and found a mission to the Cayuse Indians at Waiilatpu in the Walla Walla Valley. The Spaldings found a mission to the Nez Percé Indians at Lapwai in present-day Idaho.
None of the missionaries had very much success in converting the Indians. The Indians were very suspicious of the missionaries, and this suspicion only increased when many of the Indians came down with an illness.