He was born Landau, Germany (in the Rhine Palatinate) and he lived for many years in Morristown, New Jersey.
Notable images he popularized were:
He was well known for his political cartoons, supporting American Indians, Chinese, and advocating abolition of slavery. His biting wit was generally focused on political corruption, and was instrumental in the downfall of Boss Tweed. It was said a political cartoon drawn by Nast was used by the officials of Spain when Tweed fled justice there. Andrew Johnson was another target of his.
He shared political views with his friend Mark Twain.
Before his work in political cartoons, he worked as a correspondent of Harper's Weekly, known for his on the scene sketches of the Civil War, drawing both Border States and Southern battlefields. In 1890, he published Thomas Nast's Christmas Drawings for the Human Race. He tried to start a magazine, which failed. Theodore Roosevelt appointed him as United States' Consul General to Guayaquil Ecuador in South America. At age 62, in 1902, he died of yellow fever contracted there. His body was returned to the United States where he was interred in the Woodlawn Cemetery in The Bronx, New York.