One of the VVAF's primary causes is their "Campaign for a Landmine Free World", which works to increase awareness about the world's landmine crisis. As of 2002, the VVAF operates programs in Angola, Cambodia, El Salvador, Kosovo, Sierra Leone and Vietnam.
Since early 1998, VVAF’s "Artists for a Landmine Free World", has drawn a number of top musical artists to the cause. Some of the program’s most active members include Emmylou Harris, Sheryl Crow, Steve Earle, Nanci Griffith, Willie Nelson, Lucinda Williams, Bruce Cockburn, Bruce Springsteen, and Mary Chapin Carpenter.
The VVAF was the co-founder of the International Campaign To Ban Landmines, which received the 1997 Nobel Peace Prize. The Peace Prize was awarded jointly to coordinator Jody Williams of the VVAF and the International Campaign to Ban Landmines.