Weyapiersenwah is best remembered for leading a confederacy of tribes into battle against the forces of Anthony Wayne in what came to be known as the Battle of Fallen Timbers. This action was a victory for the U.S and led to the dissolution of the confederacy and the cessation of land under the Treaty of Greenville, of which Weyapiersenwah was one of the signatories.
Weyapiersenwah also signed the 1805 Treaty of Fort Industry, ceding parts of northern Ohio to the U.S. After this event he disappears from the historical record.