He joined industrial band Skinny Puppy in 1982, arrranging basslines and playing keyboards on the early Skinny Puppy albums Bites, Remission and the single "Stairs and Flowers". He left the band in 1984 to found his own industrial project Front Line Assembly together with Michael Balch, and later Rhys Fulber. From 1984 onward, he was known as Bill Leeb.
Other musical projects he has participated in include:
Leeb lives in Vancouver, British Columbia, Canada, and is married to Carryl-Ann Loeppke. He has no children.